BIPSXETF / FundBIOTECHNOLOGY ULTRASECTOR PROFUND
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Whether this fund clears the published standards, and the filings behind that answer. The screen runs first and nothing on the trading side can override it.
Structure, momentum, positioning and levels. Separate from the Sharia verdict above, which this side never overrides.
BIOTECHNOLOGY ULTRASECTOR PROFUND · ProFunds
159 holdings
This fund holds short positions, so exposure is counted gross — long and short both count as exposure rather than netting off, and the weights below therefore sum to 108% of net assets rather than 100%. Shares of the portfolio are shown as shares of that gross exposure.
NON-COMPLIANT At least 21.85% of portfolio weight is in non-compliant holdings — already over the 5% threshold, so the verdict is settled whatever the unmatched 62% turns out to be. Matching more holdings can only raise this share, never lower it.
159 holdings, 90 matched (43% of weight). Portfolio as of 2026-07-31, filed 2026-09-23. Source: SEC Form N-PORT.
12.80% of this portfolio’s income is non-permissible — weighted across holdings, computed over 32% of portfolio weight (64 of 159 holdings). The common approach purifies that proportion of income received — dividends — not of the position’s value. We report the ratio; what to do with it is a question for your own scholar.
Portfolio shares are withheld: coverage is below the floor needed to state one. The holdings themselves are below, because the names are evidence you can check.
All holdings (159)
| Holding | Status | Weight | Every methodology, and the debt ratio behind it |
|---|---|---|---|
| N/A | UNSCREENED | 6.70% | no in-house ratios for this holding |
| N/A | UNSCREENED | 5.15% | no in-house ratios for this holding |
| N/A | UNSCREENED | 4.12% | no in-house ratios for this holding |
| N/A | UNSCREENED | 4.12% | no in-house ratios for this holding |
| N/A | UNSCREENED | 3.16% | no in-house ratios for this holding |
| AGPXX | UNSCREENED | 2.40% | no in-house ratios for this holding |
| N/A | UNSCREENED | 1.52% | no in-house ratios for this holding |
| APOGEE THERAPEUTICS INC | UNSCREENED | 1.29% | no in-house ratios for this holding |
| N/A | UNSCREENED | 1.27% | no in-house ratios for this holding |
| N/A | UNSCREENED | 1.24% | no in-house ratios for this holding |
| ORUKA THERAPEUTICS INC | UNSCREENED | 1.20% | no in-house ratios for this holding |
| DIANTHUS THERAPEUTICS INC | UNSCREENED | 1.12% | no in-house ratios for this holding |
| ERASCA INC | UNSCREENED | 1.08% | no in-house ratios for this holding |
| TWST TWIST BIOSCIENCE CORP | COMPLIANT | 1.08% | AAOIFI1.1% Usmani13.9% Dow Jones Islamic3.2% S&P Shariah3.5% MSCI Islamic13.9% MSCI Islamic M-Series3.5% FTSE Shariah0.0% |
| KYMR KYMERA THERAPEUTICS INC | NON_COMPLIANT | 1.05% | AAOIFI0.8% Usmani4.8% Dow Jones Islamic1.7% S&P Shariah2.1% MSCI Islamic4.6% MSCI Islamic M-Series2.1% FTSE Shariah0.0% |
| SPYRE THERAPEUTICS INC | UNSCREENED | 1.04% | no in-house ratios for this holding |
| REVOLUTION MEDICINES INC | UNSCREENED | 1.04% | no in-house ratios for this holding |
| CG ONCOLOGY INC | UNSCREENED | 1.03% | no in-house ratios for this holding |
| PTGX PROTAGONIST THERAPEUTICS INC | NON_COMPLIANT | 1.03% | AAOIFI0.1% Usmani1.0% Dow Jones Islamic0.2% S&P Shariah0.3% MSCI Islamic1.0% MSCI Islamic M-Series0.3% FTSE Shariah0.0% |
| PRAXIS PRECISION MEDICINES INC | UNSCREENED | 1.02% | no in-house ratios for this holding |
| REGN REGENERON PHARMACEUTICALS INC | COMPLIANT | 1.01% | AAOIFI2.4% Usmani6.5% Dow Jones Islamic3.0% S&P Shariah2.7% MSCI Islamic4.8% MSCI Islamic M-Series2.7% FTSE Shariah4.8% |
| COGENT BIOSCIENCES INC | UNSCREENED | 0.99% | no in-house ratios for this holding |
| NTRA NATERA INC | COMPLIANT | 0.99% | AAOIFI0.5% Usmani9.0% Dow Jones Islamic0.9% S&P Shariah1.2% MSCI Islamic9.0% MSCI Islamic M-Series1.2% FTSE Shariah3.0% |
| ARWR ARROWHEAD PHARMACEUTICALS INC | COMPLIANT | 0.95% | AAOIFI— Usmani— Dow Jones Islamic— S&P Shariah— MSCI Islamic— MSCI Islamic M-Series— FTSE Shariah— |
| TVTX TRAVERE THERAPEUTICS INC | COMPLIANT | 0.95% | AAOIFI10.0% Usmani77.2% Dow Jones Islamic24.4% S&P Shariah32.6% MSCI Islamic77.2% MSCI Islamic M-Series32.6% FTSE Shariah75.4% |
| ROIVANT SCIENCES LTD | UNSCREENED | 0.95% | no in-house ratios for this holding |
| RELAY THERAPEUTICS INC | UNSCREENED | 0.95% | no in-house ratios for this holding |
| MRNA MODERNA INC | NON_COMPLIANT | 0.95% | AAOIFI2.2% Usmani11.7% Dow Jones Islamic7.4% S&P Shariah5.1% MSCI Islamic11.4% MSCI Islamic M-Series5.1% FTSE Shariah5.4% |
| VAXCYTE INC | UNSCREENED | 0.95% | no in-house ratios for this holding |
| BBIO BRIDGEBIO PHARMA INC | COMPLIANT | 0.95% | AAOIFI— Usmani— Dow Jones Islamic— S&P Shariah— MSCI Islamic— MSCI Islamic M-Series— FTSE Shariah— |
| HALO HALOZYME THERAPEUTICS INC | COMPLIANT | 0.93% | AAOIFI17.2% Usmani83.3% Dow Jones Islamic27.4% S&P Shariah30.4% MSCI Islamic83.3% MSCI Islamic M-Series30.4% FTSE Shariah83.3% |
| RYTM RHYTHM PHARMACEUTICALS INC | NON_COMPLIANT | 0.92% | AAOIFI1.8% Usmani25.1% Dow Jones Islamic2.0% S&P Shariah2.4% MSCI Islamic25.1% MSCI Islamic M-Series2.4% FTSE Shariah24.3% |
| CYTK CYTOKINETICS INC | NON_COMPLIANT | 0.92% | AAOIFI3.9% Usmani20.7% Dow Jones Islamic5.9% S&P Shariah6.2% MSCI Islamic20.7% MSCI Islamic M-Series6.2% FTSE Shariah14.3% |
| VIKING THERAPEUTICS INC | UNSCREENED | 0.91% | no in-house ratios for this holding |
| AMGN AMGEN INC | COMPLIANT | 0.91% | AAOIFI24.9% Usmani59.9% Dow Jones Islamic33.6% S&P Shariah35.1% MSCI Islamic59.9% MSCI Islamic M-Series35.1% FTSE Shariah59.9% |
| INCY INCYTE CORP | COMPLIANT | 0.90% | AAOIFI0.1% Usmani0.7% Dow Jones Islamic0.1% S&P Shariah0.1% MSCI Islamic0.3% MSCI Islamic M-Series0.1% FTSE Shariah0.0% |
| MIRM MIRUM PHARMACEUTICALS INC | COMPLIANT | 0.90% | AAOIFI11.6% Usmani73.0% Dow Jones Islamic20.3% S&P Shariah25.7% MSCI Islamic73.0% MSCI Islamic M-Series25.7% FTSE Shariah71.8% |
| ALKS ALKERMES PLC | COMPLIANT | 0.89% | AAOIFI— Usmani— Dow Jones Islamic— S&P Shariah— MSCI Islamic— MSCI Islamic M-Series— FTSE Shariah— |
| TGTX TG THERAPEUTICS INC | COMPLIANT | 0.89% | AAOIFI8.8% Usmani46.0% Dow Jones Islamic13.7% S&P Shariah17.0% MSCI Islamic46.0% MSCI Islamic M-Series17.0% FTSE Shariah45.5% |
| ABBV ABBVIE INC | COMPLIANT | 0.89% | AAOIFIpass Usmanifail Dow Jones Islamicpass S&P Shariahpass MSCI Islamicfail MSCI Islamic M-Seriespass FTSE Shariahfail |
| VRTX VERTEX PHARMACEUTICALS INC | COMPLIANT | 0.87% | AAOIFI1.6% Usmani7.2% Dow Jones Islamic1.7% S&P Shariah1.7% MSCI Islamic7.2% MSCI Islamic M-Series1.7% FTSE Shariah0.0% |
| KRYS KRYSTAL BIOTECH INC | NON_COMPLIANT | 0.87% | AAOIFI0.1% Usmani0.6% Dow Jones Islamic0.1% S&P Shariah0.2% MSCI Islamic0.6% MSCI Islamic M-Series0.2% FTSE Shariah0.0% |
| INSMED INC | UNSCREENED | 0.86% | no in-house ratios for this holding |
| SCHOLAR ROCK HOLDING CORP | UNSCREENED | 0.86% | no in-house ratios for this holding |
| GILD GILEAD SCIENCES INC | COMPLIANT | 0.86% | AAOIFI14.4% Usmani53.2% Dow Jones Islamic18.6% S&P Shariah21.4% MSCI Islamic53.2% MSCI Islamic M-Series21.4% FTSE Shariah53.2% |
| BMRN BIOMARIN PHARMACEUTICAL INC | NON_COMPLIANT | 0.85% | AAOIFI— Usmani— Dow Jones Islamic— S&P Shariah— MSCI Islamic— MSCI Islamic M-Series— FTSE Shariah— |
| UNIQURE NV | UNSCREENED | 0.84% | no in-house ratios for this holding |
| DYNE THERAPEUTICS INC | UNSCREENED | 0.84% | no in-house ratios for this holding |
| BIIB BIOGEN INC | COMPLIANT | 0.83% | AAOIFI21.2% Usmani22.5% Dow Jones Islamic27.5% S&P Shariah24.3% MSCI Islamic22.5% MSCI Islamic M-Series24.3% FTSE Shariah21.3% |
| NBIX NEUROCRINE BIOSCIENCES INC | COMPLIANT | 0.83% | AAOIFI2.9% Usmani8.6% Dow Jones Islamic3.4% S&P Shariah3.5% MSCI Islamic8.6% MSCI Islamic M-Series3.5% FTSE Shariah0.0% |
| ACAD ACADIA PHARMACEUTICALS INC | COMPLIANT | 0.82% | AAOIFIpass Usmanipass Dow Jones Islamicpass S&P Shariahpass MSCI Islamicpass MSCI Islamic M-Seriespass FTSE Shariahpass |
| EXEL EXELIXIS INC | COMPLIANT | 0.80% | AAOIFI1.2% Usmani6.7% Dow Jones Islamic1.5% S&P Shariah1.7% MSCI Islamic6.7% MSCI Islamic M-Series1.7% FTSE Shariah0.0% |
| IMMUNOVANT INC | UNSCREENED | 0.80% | no in-house ratios for this holding |
| MDGL MADRIGAL PHARMACEUTICALS INC | COMPLIANT | 0.79% | AAOIFI2.8% Usmani27.9% Dow Jones Islamic3.8% S&P Shariah4.6% MSCI Islamic27.9% MSCI Islamic M-Series4.6% FTSE Shariah27.4% |
| GRAL GRAIL INC | NON_COMPLIANT | 0.78% | AAOIFI2.5% Usmani3.2% Dow Jones Islamic4.7% S&P Shariahfail MSCI Islamic3.2% MSCI Islamic M-Seriesfail FTSE Shariah0.0% |
| CELCUITY INC | UNSCREENED | 0.78% | no in-house ratios for this holding |
| SUMMIT THERAPEUTICS INC | UNSCREENED | 0.78% | no in-house ratios for this holding |
| CRSP CRISPR THERAPEUTICS AG | NON_COMPLIANT | 0.77% | AAOIFI15.5% Usmani29.6% Dow Jones Islamic17.0% S&P Shariah16.8% MSCI Islamic29.6% MSCI Islamic M-Series16.8% FTSE Shariah22.1% |
| UTHR UNITED THERAPEUTICS CORP | NON_COMPLIANT | 0.76% | AAOIFI0.0% Usmani0.0% Dow Jones Islamic0.0% S&P Shariah0.0% MSCI Islamic0.0% MSCI Islamic M-Series0.0% FTSE Shariah0.0% |
| PTCT PTC THERAPEUTICS INC | NON_COMPLIANT | 0.74% | AAOIFI11.9% Usmani21.4% Dow Jones Islamic16.9% S&P Shariah20.0% MSCI Islamic21.2% MSCI Islamic M-Series20.0% FTSE Shariah18.2% |
| RARE ULTRAGENYX PHARMACEUTICAL INC | NON_COMPLIANT | 0.73% | AAOIFI0.0% Usmani0.0% Dow Jones Islamic0.0% S&P Shariah0.0% MSCI Islamic0.0% MSCI Islamic M-Series0.0% FTSE Shariah0.0% |
| IMMUNITYBIO INC | UNSCREENED | 0.72% | no in-house ratios for this holding |
| SELLAS LIFE SCIENCES GROUP INC | UNSCREENED | 0.69% | no in-house ratios for this holding |
| BEAM BEAM THERAPEUTICS INC | NON_COMPLIANT | 0.69% | AAOIFI8.2% Usmani17.8% Dow Jones Islamic10.4% S&P Shariah10.7% MSCI Islamic17.8% MSCI Islamic M-Series10.7% FTSE Shariah7.2% |
| BIOCRYST PHARMACEUTICALS INC | UNSCREENED | 0.69% | no in-house ratios for this holding |
| VERA THERAPEUTICS INC | UNSCREENED | 0.68% | no in-house ratios for this holding |
| IDYA IDEAYA BIOSCIENCES INC | NON_COMPLIANT | 0.66% | AAOIFI0.8% Usmani2.2% Dow Jones Islamic1.2% S&P Shariah1.1% MSCI Islamic2.2% MSCI Islamic M-Series1.1% FTSE Shariah0.0% |
| DENALI THERAPEUTICS INC | UNSCREENED | 0.64% | no in-house ratios for this holding |
| TNGX TANGO THERAPEUTICS INC | NON_COMPLIANT | 0.63% | AAOIFI0.8% Usmani3.0% Dow Jones Islamic2.2% S&P Shariah2.5% MSCI Islamic3.0% MSCI Islamic M-Series2.5% FTSE Shariah0.0% |
| ARQT ARCUTIS BIOTHERAPEUTICS INC | COMPLIANT | 0.63% | AAOIFI3.8% Usmani23.4% Dow Jones Islamic5.0% S&P Shariah6.5% MSCI Islamic23.4% MSCI Islamic M-Series6.5% FTSE Shariah22.3% |
| CELLDEX THERAPEUTICS INC | UNSCREENED | 0.62% | no in-house ratios for this holding |
| VIRIDIAN THERAPEUTICS INC | UNSCREENED | 0.59% | no in-house ratios for this holding |
| DISC MEDICINE INC | UNSCREENED | 0.59% | no in-house ratios for this holding |
| RCUS ARCUS BIOSCIENCES INC | COMPLIANT | 0.58% | AAOIFI4.0% Usmani12.3% Dow Jones Islamic5.6% S&P Shariah6.2% MSCI Islamic12.3% MSCI Islamic M-Series6.2% FTSE Shariah10.9% |
| MINERALYS THERAPEUTICS INC | UNSCREENED | 0.58% | no in-house ratios for this holding |
| IONS IONIS PHARMACEUTICALS INC | NON_COMPLIANT | 0.56% | AAOIFI21.0% Usmani67.5% Dow Jones Islamic23.0% S&P Shariah25.1% MSCI Islamic67.5% MSCI Islamic M-Series25.1% FTSE Shariah58.8% |
| ALNY ALNYLAM PHARMACEUTICALS INC | COMPLIANT | 0.56% | AAOIFI— Usmani— Dow Jones Islamic— S&P Shariah— MSCI Islamic— MSCI Islamic M-Series— FTSE Shariah— |
| VCYT VERACYTE INC | COMPLIANT | 0.56% | AAOIFI1.1% Usmani2.7% Dow Jones Islamic1.4% S&P Shariah1.6% MSCI Islamic2.7% MSCI Islamic M-Series1.6% FTSE Shariah0.0% |
| IMNM IMMUNOME INC | NON_COMPLIANT | 0.55% | AAOIFI0.2% Usmani0.8% Dow Jones Islamic0.3% S&P Shariah0.4% MSCI Islamic0.8% MSCI Islamic M-Series0.4% FTSE Shariah0.0% |
| SYNDAX PHARMACEUTICALS INC | UNSCREENED | 0.54% | no in-house ratios for this holding |
| RXRX RECURSION PHARMACEUTICALS INC | NON_COMPLIANT | 0.53% | AAOIFI3.4% Usmani5.5% Dow Jones Islamic7.3% S&P Shariah6.1% MSCI Islamic5.5% MSCI Islamic M-Series6.1% FTSE Shariah1.2% |
| SAREPTA THERAPEUTICS INC | UNSCREENED | 0.53% | no in-house ratios for this holding |
| ADMA ADMA BIOLOGICS INC | COMPLIANT | 0.53% | AAOIFIpass Usmanipass Dow Jones Islamicpass S&P Shariahpass MSCI Islamicfail MSCI Islamic M-Seriespass FTSE Shariahpass |
| KODIAK SCIENCES INC | UNSCREENED | 0.50% | no in-house ratios for this holding |
| NTLA INTELLIA THERAPEUTICS INC | NON_COMPLIANT | 0.49% | AAOIFI4.1% Usmani8.6% Dow Jones Islamic5.1% S&P Shariah4.1% MSCI Islamic8.6% MSCI Islamic M-Series4.1% FTSE Shariah0.0% |
| AGIO AGIOS PHARMACEUTICALS INC | NON_COMPLIANT | 0.48% | AAOIFIfail Usmanifail Dow Jones Islamicfail S&P Shariahfail MSCI Islamicfail MSCI Islamic M-Seriesfail FTSE Shariahfail |
| IOVA IOVANCE BIOTHERAPEUTICS INC | COMPLIANT | 0.47% | AAOIFI1.2% Usmani5.0% Dow Jones Islamic2.9% S&P Shariah2.4% MSCI Islamic5.0% MSCI Islamic M-Series2.4% FTSE Shariah0.0% |
| NRIX NURIX THERAPEUTICS INC | NON_COMPLIANT | 0.46% | AAOIFI2.1% Usmani10.9% Dow Jones Islamic4.1% S&P Shariah5.0% MSCI Islamic10.9% MSCI Islamic M-Series5.0% FTSE Shariah0.0% |
| PALVELLA THERAPEUTICS INC | UNSCREENED | 0.46% | no in-house ratios for this holding |
| NVAX NOVAVAX INC | NON_COMPLIANT | 0.44% | AAOIFI17.3% Usmani31.1% Dow Jones Islamic21.2% S&P Shariah22.9% MSCI Islamic30.5% MSCI Islamic M-Series22.9% FTSE Shariah30.5% |
| VCEL VERICEL CORP | COMPLIANT | 0.44% | AAOIFI4.0% Usmani18.5% Dow Jones Islamic4.4% S&P Shariah4.4% MSCI Islamic18.4% MSCI Islamic M-Series4.4% FTSE Shariah0.0% |
| BIOHAVEN LTD | UNSCREENED | 0.41% | no in-house ratios for this holding |
| CDNA CAREDX INC | COMPLIANT | 0.40% | AAOIFI— Usmani— Dow Jones Islamic— S&P Shariah— MSCI Islamic— MSCI Islamic M-Series— FTSE Shariah— |
| STOK STOKE THERAPEUTICS INC | NON_COMPLIANT | 0.36% | AAOIFI0.1% Usmani0.7% Dow Jones Islamic0.2% S&P Shariah0.3% MSCI Islamic0.7% MSCI Islamic M-Series0.3% FTSE Shariah0.0% |
| PGEN PRECIGEN INC | NON_COMPLIANT | 0.36% | AAOIFI3.9% Usmani57.7% Dow Jones Islamic9.9% S&P Shariah12.7% MSCI Islamic57.7% MSCI Islamic M-Series12.7% FTSE Shariah55.1% |
| TYRA TYRA BIOSCIENCES INC | COMPLIANT | 0.36% | AAOIFI0.3% Usmani1.5% Dow Jones Islamic0.5% S&P Shariah0.6% MSCI Islamic1.5% MSCI Islamic M-Series0.6% FTSE Shariah0.0% |
| VIR VIR BIOTECHNOLOGY INC | NON_COMPLIANT | 0.34% | AAOIFI6.1% Usmani7.7% Dow Jones Islamic8.6% S&P Shariah8.1% MSCI Islamic7.7% MSCI Islamic M-Series8.1% FTSE Shariah0.0% |
| ZBIO ZENAS BIOPHARMA INC | NON_COMPLIANT | 0.34% | AAOIFI3.9% Usmani11.3% Dow Jones Islamic8.0% S&P Shariah— MSCI Islamic11.3% MSCI Islamic M-Series— FTSE Shariah11.2% |
| ANAPTYSBIO INC | UNSCREENED | 0.34% | no in-house ratios for this holding |
| FIRST TRACKS BIOTHERAPEUTICS INC | UNSCREENED | 0.33% | no in-house ratios for this holding |
| ABSI ABSCI CORP | COMPLIANT | 0.32% | AAOIFI— Usmanifail Dow Jones Islamicfail S&P Shariah— MSCI Islamicfail MSCI Islamic M-Seriesfail FTSE Shariahfail |
| PURR HYPERLIQUID STRATEGIES INC | NON_COMPLIANT | 0.32% | AAOIFI0.0% Usmani0.0% Dow Jones Islamic0.0% S&P Shariah0.0% MSCI Islamic0.0% MSCI Islamic M-Series0.0% FTSE Shariah0.0% |
| CULLINAN THERAPEUTICS INC | UNSCREENED | 0.32% | no in-house ratios for this holding |
| XENCOR INC | UNSCREENED | 0.31% | no in-house ratios for this holding |
| CRVS CORVUS PHARMACEUTICALS INC | COMPLIANT | 0.31% | AAOIFI— Usmani— Dow Jones Islamic— S&P Shariah— MSCI Islamic— MSCI Islamic M-Series— FTSE Shariah— |
| VOR VOR BIOPHARMA INC | NON_COMPLIANT | 0.30% | AAOIFI0.3% Usmani0.6% Dow Jones Islamic0.9% S&P Shariah1.2% MSCI Islamic0.6% MSCI Islamic M-Series1.2% FTSE Shariah0.0% |
| AVALO THERAPEUTICS INC | UNSCREENED | 0.30% | no in-house ratios for this holding |
| ARDX ARDELYX INC | COMPLIANT | 0.29% | AAOIFI— Usmani— Dow Jones Islamic— S&P Shariah— MSCI Islamic— MSCI Islamic M-Series— FTSE Shariah— |
| ORIC ORIC PHARMACEUTICALS INC | COMPLIANT | 0.29% | AAOIFI0.3% Usmani0.8% Dow Jones Islamic0.4% S&P Shariah0.4% MSCI Islamic0.8% MSCI Islamic M-Series0.4% FTSE Shariah0.0% |
| GLUE MONTE ROSA THERAPEUTICS INC | NON_COMPLIANT | 0.28% | AAOIFI4.3% Usmani5.5% Dow Jones Islamic4.5% S&P Shariah5.9% MSCI Islamic5.5% MSCI Islamic M-Series5.9% FTSE Shariah0.0% |
| MNKD MANNKIND CORP | NON_COMPLIANT | 0.27% | AAOIFI34.1% Usmani45.2% Dow Jones Islamic23.3% S&P Shariah24.3% MSCI Islamic45.2% MSCI Islamic M-Series24.3% FTSE Shariah43.6% |
| INHIBRX BIOSCIENCES INC | UNSCREENED | 0.26% | no in-house ratios for this holding |
| TSHA TAYSHA GENE THERAPIES INC | NON_COMPLIANT | 0.26% | AAOIFI3.1% Usmani12.1% Dow Jones Islamic5.9% S&P Shariah7.4% MSCI Islamic12.0% MSCI Islamic M-Series7.4% FTSE Shariah10.5% |
| ANNX ANNEXON INC | COMPLIANT | 0.26% | AAOIFI— Usmani— Dow Jones Islamic— S&P Shariah— MSCI Islamic— MSCI Islamic M-Series— FTSE Shariah— |
| OLMA OLEMA PHARMACEUTICALS INC | NON_COMPLIANT | 0.25% | AAOIFI0.1% Usmani0.1% Dow Jones Islamic0.1% S&P Shariah0.1% MSCI Islamic0.1% MSCI Islamic M-Series0.1% FTSE Shariah0.0% |
| REPLIMUNE GROUP INC | UNSCREENED | 0.25% | no in-house ratios for this holding |
| SIONNA THERAPEUTICS INC | UNSCREENED | 0.25% | no in-house ratios for this holding |
| JBIO JADE BIOSCIENCES INC | NON_COMPLIANT | 0.24% | AAOIFI0.0% Usmani0.1% Dow Jones Islamic0.1% S&P Shariah0.1% MSCI Islamic0.1% MSCI Islamic M-Series0.1% FTSE Shariah0.0% |
| BICARA THERAPEUTICS INC | UNSCREENED | 0.24% | no in-house ratios for this holding |
| JANX JANUX THERAPEUTICS INC | NON_COMPLIANT | 0.24% | AAOIFI1.7% Usmani2.1% Dow Jones Islamic1.4% S&P Shariah1.4% MSCI Islamic2.1% MSCI Islamic M-Series1.4% FTSE Shariah0.0% |
| GERON CORP | UNSCREENED | 0.23% | no in-house ratios for this holding |
| KURA ONCOLOGY INC | UNSCREENED | 0.22% | no in-house ratios for this holding |
| ARRIVENT BIOPHARMA INC | UNSCREENED | 0.21% | no in-house ratios for this holding |
| CTMX CYTOMX THERAPEUTICS INC | NON_COMPLIANT | 0.20% | AAOIFI0.7% Usmani1.5% Dow Jones Islamic1.3% S&P Shariah1.8% MSCI Islamic1.5% MSCI Islamic M-Series1.8% FTSE Shariah0.0% |
| RIGL RIGEL PHARMACEUTICALS INC | COMPLIANT | 0.19% | AAOIFI5.0% Usmani8.8% Dow Jones Islamic9.0% S&P Shariah11.3% MSCI Islamic8.8% MSCI Islamic M-Series11.3% FTSE Shariah8.6% |
| IRWD IRONWOOD PHARMACEUTICALS INC | NON_COMPLIANT | 0.19% | AAOIFI30.0% Usmani74.1% Dow Jones Islamic45.1% S&P Shariah27.1% MSCI Islamic74.1% MSCI Islamic M-Series27.1% FTSE Shariah70.0% |
| ALTIMMUNE INC | UNSCREENED | 0.18% | no in-house ratios for this holding |
| ALLOGENE THERAPEUTICS INC | UNSCREENED | 0.18% | no in-house ratios for this holding |
| SANA BIOTECHNOLOGY INC | UNSCREENED | 0.18% | no in-house ratios for this holding |
| SOLID BIOSCIENCES INC | UNSCREENED | 0.17% | no in-house ratios for this holding |
| DMRA DAMORA THERAPEUTICS INC | NON_COMPLIANT | 0.17% | AAOIFI0.0% Usmani0.0% Dow Jones Islamic0.0% S&P Shariah0.0% MSCI Islamic0.0% MSCI Islamic M-Series0.0% FTSE Shariah0.0% |
| CANDEL THERAPEUTICS INC | UNSCREENED | 0.16% | no in-house ratios for this holding |
| VSTM VERASTEM INC | NON_COMPLIANT | 0.16% | AAOIFI6.3% Usmani16.1% Dow Jones Islamic8.5% S&P Shariah10.1% MSCI Islamic16.1% MSCI Islamic M-Series10.1% FTSE Shariah14.8% |
| RGNX REGENXBIO INC | NON_COMPLIANT | 0.15% | AAOIFI11.7% Usmani17.8% Dow Jones Islamic14.0% S&P Shariah12.0% MSCI Islamic17.8% MSCI Islamic M-Series12.0% FTSE Shariah0.0% |
| IMMX IMMIX BIOPHARMA INC | NON_COMPLIANT | 0.14% | AAOIFI0.1% Usmani0.4% Dow Jones Islamic0.4% S&P Shariah0.5% MSCI Islamic0.4% MSCI Islamic M-Series0.5% FTSE Shariah0.0% |
| SVRA SAVARA INC | NON_COMPLIANT | 0.14% | AAOIFI2.7% Usmani15.7% Dow Jones Islamic3.9% S&P Shariah4.2% MSCI Islamic15.7% MSCI Islamic M-Series4.2% FTSE Shariah15.7% |
| OCGN OCUGEN INC | NON_COMPLIANT | 0.14% | AAOIFI1.2% Usmani4.5% Dow Jones Islamic1.5% S&P Shariah1.7% MSCI Islamic4.5% MSCI Islamic M-Series1.7% FTSE Shariah1.4% |
| FDMT 4D MOLECULAR THERAPEUTICS INC | NON_COMPLIANT | 0.13% | AAOIFI4.7% Usmani8.0% Dow Jones Islamic9.8% S&P Shariah6.8% MSCI Islamic8.0% MSCI Islamic M-Series6.8% FTSE Shariah4.0% |
| ABUS ARBUTUS BIOPHARMA CORP | NON_COMPLIANT | 0.13% | AAOIFI0.1% Usmani0.2% Dow Jones Islamic0.1% S&P Shariah0.1% MSCI Islamic0.2% MSCI Islamic M-Series0.1% FTSE Shariah0.0% |
| PRME PRIME MEDICINE INC | NON_COMPLIANT | 0.12% | AAOIFI16.8% Usmani45.2% Dow Jones Islamic21.9% S&P Shariah18.8% MSCI Islamic45.2% MSCI Islamic M-Series18.8% FTSE Shariah0.0% |
| CABALETTA BIO INC | UNSCREENED | 0.11% | no in-house ratios for this holding |
| COMPASS THERAPEUTICS INC | UNSCREENED | 0.10% | no in-house ratios for this holding |
| EBS EMERGENT BIOSOLUTIONS INC | NON_COMPLIANT | 0.10% | AAOIFI184.7% Usmani52.7% Dow Jones Islamic132.4% S&P Shariah158.7% MSCI Islamic52.7% MSCI Islamic M-Series158.7% FTSE Shariah52.1% |
| MDXG MIMEDX GROUP INC | COMPLIANT | 0.10% | AAOIFI2.5% Usmani6.1% Dow Jones Islamic1.9% S&P Shariah1.8% MSCI Islamic6.1% MSCI Islamic M-Series1.8% FTSE Shariah6.1% |
| PRTA PROTHENA CORP PLC | NON_COMPLIANT | 0.09% | AAOIFI1.4% Usmani2.3% Dow Jones Islamic1.2% S&P Shariah0.8% MSCI Islamic2.3% MSCI Islamic M-Series0.8% FTSE Shariah0.0% |
| CATX PERSPECTIVE THERAPEUTICS INC | NON_COMPLIANT | 0.09% | AAOIFI1.1% Usmani1.0% Dow Jones Islamic1.1% S&P Shariah1.0% MSCI Islamic1.0% MSCI Islamic M-Series1.0% FTSE Shariah0.4% |
| SPRY ARS PHARMACEUTICALS INC | NON_COMPLIANT | 0.09% | AAOIFI17.3% Usmani38.7% Dow Jones Islamic8.7% S&P Shariah9.8% MSCI Islamic38.7% MSCI Islamic M-Series9.8% FTSE Shariah38.7% |
| VNDA VANDA PHARMACEUTICALS INC | NON_COMPLIANT | 0.09% | AAOIFI5.1% Usmani5.5% Dow Jones Islamic4.9% S&P Shariah5.2% MSCI Islamic3.8% MSCI Islamic M-Series5.2% FTSE Shariah0.0% |
| OVID OVID THERAPEUTICS INC | NON_COMPLIANT | 0.09% | AAOIFI2.3% Usmani5.5% Dow Jones Islamic8.0% S&P Shariah7.3% MSCI Islamic5.5% MSCI Islamic M-Series7.3% FTSE Shariah0.0% |
| LEXEO THERAPEUTICS INC | UNSCREENED | 0.08% | no in-house ratios for this holding |
| ACHIEVE LIFE SCIENCES INC | UNSCREENED | 0.07% | no in-house ratios for this holding |
| MYGN MYRIAD GENETICS INC | NON_COMPLIANT | 0.07% | AAOIFI69.0% Usmani32.9% Dow Jones Islamic25.9% S&P Shariah18.2% MSCI Islamic32.9% MSCI Islamic M-Series18.2% FTSE Shariah18.9% |
| CAPRICOR THERAPEUTICS INC | UNSCREENED | 0.07% | no in-house ratios for this holding |
| SGMT SAGIMET BIOSCIENCES INC | NON_COMPLIANT | 0.06% | AAOIFI0.3% Usmani0.7% Dow Jones Islamic1.0% S&P Shariah1.2% MSCI Islamic0.7% MSCI Islamic M-Series1.2% FTSE Shariah0.0% |
| BRIDGEBIO ONCOLOGY THERAPEUTICS INC | UNSCREENED | 0.05% | no in-house ratios for this holding |
| MPLT MAPLIGHT THERAPEUTICS INC | NON_COMPLIANT | 0.05% | AAOIFI0.3% Usmani0.5% Dow Jones Islamic— S&P Shariah— MSCI Islamic0.5% MSCI Islamic M-Series— FTSE Shariah0.0% |
| N/A | UNSCREENED | 0.02% | no in-house ratios for this holding |
| N/A | UNSCREENED | 0.02% | no in-house ratios for this holding |
| N/A | UNSCREENED | 0.01% | no in-house ratios for this holding |
The published standards disagree about this fund by 16 points of portfolio weight — 20.8% of it passes AAOIFI, 4.6% passes MSCI Islamic. Which number is yours depends on which standard you follow.
These bars are the financial-ratio result under each standard — debt, receivables and interest income. They do not screen what the business does, so a holding can pass every ratio here and still be questionable or non-compliant on activity. The blended verdict above accounts for both.
ratios pass on 20.8% ratios fail on 17.0% 70.3% not rated under AAOIFI
ratios pass on 8.3% ratios fail on 29.9% 70.0% not rated under Usmani
ratios pass on 18.5% ratios fail on 19.3% 70.3% not rated under Dow Jones Islamic
ratios pass on 18.7% ratios fail on 17.7% 71.7% not rated under S&P Shariah
ratios pass on 4.6% ratios fail on 35.2% 68.3% not rated under MSCI Islamic
ratios pass on 18.7% ratios fail on 18.0% 71.4% not rated under MSCI Islamic M-Series
ratios pass on 8.5% ratios fail on 29.4% 70.2% not rated under FTSE Shariah
90 of 159 listed holdings carry our own per-methodology verdicts (46% of weight). The rest hold a provider verdict with no methodology breakdown, and are counted as rated by none. Of those, 76 (38% of weight) also carry the underlying debt ratio; the rest show a verdict without the figure behind it.
| Non-compliant holding | Weight |
|---|---|
| KYMR KYMERA THERAPEUTICS INC | 1.05% |
| PTGX PROTAGONIST THERAPEUTICS INC | 1.03% |
| MRNA MODERNA INC | 0.95% |
| RYTM RHYTHM PHARMACEUTICALS INC | 0.92% |
| CYTK CYTOKINETICS INC | 0.92% |
| KRYS KRYSTAL BIOTECH INC | 0.87% |
| BMRN BIOMARIN PHARMACEUTICAL INC | 0.85% |
| GRAL GRAIL INC | 0.78% |
| CRSP CRISPR THERAPEUTICS AG | 0.77% |
| UTHR UNITED THERAPEUTICS CORP | 0.76% |
Trade setup
Whether the technical picture shows an edge right now. Separate from the Sharia verdict, which this side never overrides.
BIOTECHNOLOGY ULTRASECTOR PROFUND (BIPSX) is currently considered not halal (non-compliant), per our own look-through to its filed holdings. See its filed holdings and the weight breakdown below for the reasoning.
Screened on its holdings, not its name
HTR reads the fund's filed holdings and screens each one, then reports the result by weight. A holding it cannot cover far enough is reported as unrated rather than counted as a pass.
| Holding | Weight | Verdict |
|---|---|---|
| N/Anot matched to a ticker | 6.70% | Not screened |
| N/Anot matched to a ticker | 5.15% | Not screened |
| N/Anot matched to a ticker | 4.12% | Not screened |
| N/Anot matched to a ticker | 4.12% | Not screened |
| N/Anot matched to a ticker | 3.16% | Not screened |
| AGPXXnot matched to a ticker | 2.40% | Not screened |
| N/Anot matched to a ticker · short | 1.52% | Not screened |
| APOGEE THERAPEUTICS INCnot matched to a ticker | 1.29% | Not screened |
| N/Anot matched to a ticker · short | 1.27% | Not screened |
| N/Anot matched to a ticker | 1.24% | Not screened |
Top 10 of 159 holdings, 31.0% of the fund by weight. Every holding is screened, not only these.
What holds the number back
The positions keeping this fund short of 100% compliant by weight.
- N/Anot screened6.70%
- N/Anot screened5.15%
- N/Anot screened4.12%
- N/Anot screened4.12%
- N/Anot screened3.16%
- AGPXXnot screened2.40%
What changed, and when
Verdict history for BIPSX. A verdict that never moved is recorded too, so a quiet history reads as measured rather than missing.
- 2026-09-07 No change recorded No verdict change for BIPSX has been recorded since tracking began. The scan ledger records that the compliance detectors ran, not which symbols each pass covered.
ℹ️ no compliance scan has run for 2 days - this is not a reading of today
Pinch or scroll to zoom · drag to pan — both axes move · double-click to reset
This fund prices once a day, so its bars carry no intraday high or low — floor-trader pivots are not defined for it.
Price Forecast
The range is measured volatility (ATR over the horizon), not a target — a wider band means a more volatile asset, not a stronger view. The direction is the indicator tally below. Every forecast is recorded when made and scored against the real price when it comes due, including the wrong ones. Not a recommendation, and not a fatwa.
Technical Summary
Standard indicator thresholds (RSI 30/70, Stochastic 20/80, CCI ±100, Williams %R −80/−20, MACD histogram sign, price vs. average) computed on daily bars. A summary of what common indicators say — not a recommendation, and not this site's own trading verdict.
Every indicator, and what it reads
| Indicator | Value | Signal |
|---|---|---|
| RSI (14) | 49.50 | NEUTRAL |
| Stochastic %K (14) | 71.45 | NEUTRAL |
| CCI (20) | 7.46 | NEUTRAL |
| Williams %R (14) | -28.55 | NEUTRAL |
| MACD (12,26,9) | -0.04 | SELL |
| ROC (10) | 1.88 | BUY |
| Momentum (10) | 0.85 | BUY |
| EMA (10) | 44.86 | BUY |
| SMA (10) | 44.56 | BUY |
| EMA (20) | 45.82 | BUY |
| SMA (20) | 46.01 | BUY |
| EMA (30) | 46.52 | SELL |
| SMA (30) | 46.84 | SELL |
| EMA (50) | 47.02 | SELL |
| SMA (50) | 48.69 | SELL |
| EMA (100) | 45.95 | BUY |
| SMA (100) | 46.80 | SELL |
| EMA (200) | 42.07 | BUY |
| SMA (200) | 41.89 | BUY |
SMC — Top Down
Market structure by timeframe, read from real bars. A bias per timeframe rather than a forecast — timeframes disagreeing is information, not noise.
Before you act on this
The questions worth asking about any verdict on this page, answered plainly.
Is a fund screened on its name?
No. HTR reads the fund's filed holdings and screens each one, then reports the result by weight. A fund marketed as Islamic still gets the same look-through as any other.
What does unrated weight mean?
It is the share of the fund whose holdings HTR cannot cover far enough to rate. It is reported as unrated rather than counted as compliant, because a holding nobody screened should not look like one that passed.
Does the issuer's board make it compliant?
It matters, and it is noted, but it does not replace the look-through. The board's judgement and the holdings screen are shown separately so you can see when they agree and when they do not.
How often is this re-screened?
When the fund files new holdings, and on a rolling basis besides. The date on the verdict above is the last time this fund was actually recomputed.
Open research, not a fatwa. HTR applies published screening standards to filings and publishes what they say, including when they disagree. Nothing here is financial advice or a recommendation to buy or sell. Verdicts can change when new filings land.
Compare with
Same screen, different answers. Comparison is where the standards disagreeing becomes useful rather than confusing.
Peer screening computing — it will appear here on its own.
AI Summary
Plain-language summary of the evidence already on this page — the Sharia screen, structure, momentum, and order flow above. It explains the read; it doesn't make the call. Generated on demand (a live AI call), never run automatically.